Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail.

This job offer is accessible to all, regardless of gender.

Job title Principal Biostatistician

• Location: Marcy l’Etoile, France

• Job type: Permanent

About the job

As clinical Principal Biostatistician within our Vaccines Biostatistical Sciences team, you are the ultimate scientific owner of all statistical deliverables for your assigned study(ies) and project activities, bringing your passion for clinical trials design, statistical analysis, transforming insights into action and revolutionizing how we approach AI-driven evidence generation.

About Sanofi:

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Job Summary

Assume responsibility for methodological and statistical aspects of one or several clinical studies, with general direction from Statistical Project Leader and/or Bios Franchise Lead. He/she will provide critical input on the design and analysis of our clinical trial data so that accurate assessments are made for decision-making, while ensuring compliance with regulatory expectations. He/she may be involved in supporting some project activities.

He/she will also be supporting the various changes linked to the development of new tools and processes.

Main responsibilities:

• Act as the global biostatistics representative at clinical trial(s) level, contributing actively on clinical trial design (including sample size justification, estimand,…), owning the development of the Statistical Analysis Plan (SAP) and delivery of statistical analyses and key results interpretation with scientists

• Propose, prepare, and perform exploratory and ad-hoc data analyses at study or cross-studies level to inform future trial objectives, internal decision making or submissions

• Collaborate closely with cross-functional study team on the design (clinician), on safety monitoring (pharmacovigilance), on statistical programmers for the preparation and production of statistical reports and appendices at trial or asset level

• Manage and oversee outsourced activities with external partners (CROs), ensuring quality, timely delivery and oversight documentation

• Participate in project activities such as Clinical Development Plan development, decision-making meetings, integrated analyses, and dossier preparation, submission, and follow-up

• Leverage AI & Machine Learning to augment biostatistics contribution – Leverage AI & Machine Learning in the analysis of clinical and real-world data. Explore and implement AI-powered tools (e.g., LLMs, code generation, automated QC) to accelerate and enhance analyses workflows—from data wrangling to output generation and validation

• Contribute to process improvement and tool/automation development initiatives

Required Qualifications

• Experience : Proven initial experience in pharmaceutical industry, preferably in clinical trials and data science. Proven track record in statistical analysis and methodology within a regulated environment

• Technical Skills : Deep expertise in R programming (required), proficiency in Python and/or SAS (a plus). Strong knowledge basis in advanced statistical methods (e.g., Bayesian statistics, linear and non-linear modelling) and Machine Learning. AI knowledge is a plus. Familiarity with clinical trial data structures and regulatory requirements

• Soft Skills : Excellent problem-solving and analytical mindset; Effective verbal and written communication skills. Strong ability of teamwork and adaptability in a fast-paced setting. Ability to influence across functions in a global environment and drive organizational change

• Education: PhD in Biostatistics, Data Science, or related discipline or a Master's degree with equivalent experience. Preferred: coursework or projects involving healthcare, life sciences, or clinical research data

• Digital Acumen : Ability to implement automation and digital transformation initiatives

• Languages : Fluent in English (required)

Why choose us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Pursue Progress. Discover Extraordinary.

Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.